This study is a contribution to the study of the spatial evolution of the properties of the municipal lake of Yaounde-Cameroon. The objective was the characterization of the physico-chemical, bacteriological and organoleptic parameters of water of this lake in order to provide the scientifically exploitable data. To understand the sources and the evolution of the pollution of this lake, we carried out on the surface of water, fifteen samples horizontally representative and arranged on the longitudinal axis and the transverse axis of this one. Analyzes of the parameters of these samples allowed us to establish that three classes of water coexist within the expanse of this lake, in this case water of class 5 (colour = 380.3 mgPt-Co/L, conductivity at 20 °C = 3620 μS/cm, pH = 6.2, dissolved oxygen = 0.4 mg/L) at its its eastern bank; water of class 4 (101.4 ≤ colour ≤ 172.8 mgPt-Co/L, 25.7 ≤ temperature ≤ 26.1 °C, 6.6 ≤ pH ≤ 7.0, 8.9 ≤ BOD5 ≤ 20.7 mg/L, 43.0.103 ≤ total coliforms ≤ 49.7.103 CFU/100 mL) around 300 meters from its tributary and water of class 3 (54.9 ≤ colour ≤ 93.4 mgPt-Co/L, 24.2 ≤ temperature ≤ 25.5 °C ; 7.4 ≤ pH ≤ 7.7, 6.6 ≤ BOD5 ≤ 8.7 mg/L) in the rest of the lake. These water classes, as indicated above, cause this lake to be polluted differently. The study also allowed us to identify two directions of self-purification within the lake expanse.