Today, most countries in the world are gearing up by innovation, seeking to increase productivity and improve their economic situation, and one of the important centers for innovative activities is the incubator centered companies. The majority of companies based in incubator centers are startups companies. Considering that the failure rate of new firms in the early years of formation is greater, research should be conducted on the success factors of these companies. Therefore, the present study aims to identify the key factors for the success of knowledge-based companies Relied on academic incubator centers and it was carried out with the Meta synthesis method. Meta synthesis requires that the researcher carry out a thorough and in-depth review, combining the findings of relevant qualitative research. Using the Meta synthesis method, evaluated over 38 articles in the field of knowledge-based companies. Content mining was used to extract the dimensions and codes, and the significance and priority of each was determined by the use of the quantitative Shannon entropy method. 13 codes, 4 general concepts and 2 categories were identified by reviewing 38 articles. Shannon’s entropy was determined based on the results of the quantitative analysis. To evaluate the quality, the results are presented to one of the experts to be examined by the Kappa index Using SPSS software; a significant number of 0.000 and an index value of 0.706 were calculated. So it can be claimed that the extraction of the codes had a good reliability. The most important factor for the success of the companies located in the incubator centers of Sistan and Baluchistan University is the marketing and sales capabilities that have the highest coefficient and have the highest rankings in total. Based on the findings, it was found that the factors of marketing and sales capabilities, the presence of specialized staff and information technology related infrastructure (software, hardware, network, and brain ware), respectively, have the most impact on the success of knowledge-based companies Relied on university incubator centers.