Knowledge is a key factor and strategic resource for gaining assets and non-functional organizational capabilities. Knowledge Management is the knowledgeable process of creating, validating, presenting, distributing and using the knowledge in an organization. Successful organizations consider human resource development as a fundamental principle. This study aims to investigate the Knowledge Management Effect on Managers Skills Improvement. The present study is practical and the data collection method is descriptive. The statistical population includes 200 managers in Shiraz Municipality, out of whom 128 people were selected as the statistics sample by simple random sampling and Morgan’s table. The standard questionnaire of knowledge management variables and managers skills were used as the instruments for data collection. And Cronbach’s Alpha Coefficient confirmed the questionnaire validity to be 0.92. The data analysis of the study was investigated by Partial Least Squares and Statistical Package for Social Science software. The results show that knowledge management has a positive and significant effect on human, operational and perceptual skills of Shiraz Municipality managers.